Structure of PDB 6baa Chain H

Receptor sequence
>6baaH (length=1317) Species: 10034 (Cricetus cricetus) [Search protein sequence]
CGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQS
SKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLH
LYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFV
KFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVK
PPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIAKLPI
AMRALTNYQRLCVAFDAARAIWRALCHAFGRRLILSSTFRILADLLGFAG
PLCIFGIVDHLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAI
QTKIYNKIMHMSAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVIL
LYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTNE
MLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIP
IAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTV
KALVSVQKLSEFLSCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVG
QVGCGKSSLLLATLGEMQKVSGAVFWNSNLPVAYASQKPWLLNATVEENI
TFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRI
SVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVT
HKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWACTKYLSSAG
ILLLSLLVFSQLLKHMVLVAIDYWLAKWTDYAMVFTLLCSLGIVLCLVTS
VTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTID
QHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFR
VASRDLQQLDDTTQLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDS
NNIASLFLTAANRWLEVCMEYIGACVVLIAAATSISNSLSAGLVGLGLTY
ALMVSNYLNWMVRNLADMEIQLGAVKRIHALLGKIQIQNLSVRYDSSLKP
VLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDI
AKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQL
KLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATA
SIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEF
DKPETLLSQKDSVFASF
3D structure
PDB6baa Anti-diabetic drug binding site in a mammalian KATPchannel revealed by Cryo-EM.
ChainH
Resolution3.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GBM H Y377 F433 N437 L592 S1238 T1242 N1245 R1246 Y336 F382 N386 L541 S1005 T1009 N1012 R1013
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6baa, PDBe:6baa, PDBj:6baa
PDBsum6baa
PubMed29035201
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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