Structure of PDB 5ywb Chain H

Receptor sequence

>5ywbH (length=1322) Species: 10036 (Mesocricetus auratus)

NGCFVDALNVVPHVFLLFITFPILFIGWGSTWLHFPGHNLRWILTFILLF
VLVCEIAEGILSDHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIAL
LIYWTLAFITKTIKFVKFYDHLRFCLTGLLVILYGMLLLVEVNVIRVRRY
IFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPI
DLRAIGKLPIAMRALTNYQRLCVAFDAQARKGARAIWRALCHAFGRRLIL
SSTFRILADLLGFAGPLCIFGIVDHLGKNAYVLAVLLFLALLLQRTFLQA
SYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDT
NQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQY
FVATKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVT
RRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSV
AFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREECVQ
IIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEM
QKVSGAVFWGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSL
QPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFS
ALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTI
QREGTLKDFQRSERACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLA
KWTDSDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNR
IILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSAL
TVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHF
AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEY
IGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLAD
MEIQLGAVKRIHALLKTEAESYEGPSLIPKNWPDQGKIQIQNLSVRYDSS
LKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDG
IDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEI
AQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDE
ATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAI
LEFDKPETLLSQKDSVFASFVR

3D structure

• PDB: 5ywb Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
• Chain: H
• Resolution: 5.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	H	W688 G716 G718 K719 S720 S721 Q775 E1480 S1483	W558 G586 G588 K589 S590 S591 Q617 E1223 S1226
BS02	ADP	H	E1114 Y1354 G1382 G1384 K1385 S1386 S1387	E860 Y1097 G1125 G1127 K1128 S1129 S1130
BS03	MG	H	S720 Q775	S590 Q617

Gene Ontology

Molecular Function

• GO:0005267 potassium channel activity
• GO:0005524 ATP binding
• GO:0008281 sulfonylurea receptor activity
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006813 potassium ion transport
• GO:0055085 transmembrane transport
• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:5ywb, PDBe:5ywb, PDBj:5ywb
• PDBsum: 5ywb
• PubMed: 29594720
• UniProt: Q09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)