Structure of PDB 5ykf Chain H

Receptor sequence
>5ykfH (length=1309) Species: 10036 (Mesocricetus auratus) [Search protein sequence]
NGCFVDALNVVPHVFLLFITFPILFIGWGSTWLHFPGHNLRWILTFILLF
VLVCEIAEGILSDHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIAL
LIYWTLAFITKTIKFVKFYDHLRFCLTGLLVILYGMLLLVEVNVIRVRRY
IFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPI
DLRAIGKLPIAMRALTNYQRLCVAFDAQARKDGARAIWRALCHAFGRRLI
LSSTFRILADLLGFAGPLCIFGIVDHLGKNAYVLAVLLFLALLLQRTFLQ
ASYYVAIETGINLRGAIQTKIYNKIMHLSTSNEMTAGQICNLVAIDTNQL
MWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVA
TKLSQAQRSTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRK
EMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFA
SLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSCVQIIGGFFTWT
PDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFW
GPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPH
GDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDH
LMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDF
QRSEIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSD
QSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPM
RFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYV
TPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEG
LTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVV
LIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLG
AVKRIHALLKTPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIS
PGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRS
RLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGG
LDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENIL
QKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQK
DSVFASFVR
3D structure
PDB5ykf Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
ChainH
Resolution4.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GBM H R306 Y377 I381 F433 L434 N437 L592 T1242 R1246 R256 Y303 I307 F355 L356 N359 L514 T982 R986
BS02 AGS H W688 G716 C717 G718 K719 S720 S721 Q775 W549 G577 C578 G579 K580 S581 S582 Q608
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0043531 ADP binding
GO:0044325 transmembrane transporter binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0001508 action potential
GO:0006813 potassium ion transport
GO:0031669 cellular response to nutrient levels
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0046676 negative regulation of insulin secretion
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0061535 glutamate secretion, neurotransmission
GO:0071805 potassium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008282 inward rectifying potassium channel
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0098793 presynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ykf, PDBe:5ykf, PDBj:5ykf
PDBsum5ykf
PubMed29594720
UniProtA0A1U7R319

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