Structure of PDB 5vof Chain H

Receptor sequence
>5vofH (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF
RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHERQSTRLKMLEVPYVD
RNSCKLSSSFIITQNMFCAGYDTKQEDACQGDAGGPHVTRFKDTYFVTGI
VSWGEGCARKGKYGIYTKVTAFLKWIDRSMK
3D structure
PDB5vof Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass.
ChainH
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 A195
Catalytic site (residue number reindexed from 1) H42 D88 Q180 G181 D182 A183
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna H L59 Y60 V88 I89 K90 N92 R93 K236 W237 R240 L44 Y45 V74 I75 K76 N78 R79 K224 W225 R228
BS02 RIV H E97 T98 Y99 F174 A190 V213 W215 G216 G219 G226 I227 Y228 E83 T84 Y85 F160 A178 V201 W203 G204 G206 G214 I215 Y216 BindingDB: IC50=700nM,Ki=0.400000nM
BS03 CA H D70 N72 Q75 E76 E80 D56 N58 Q61 E62 E66
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5vof, PDBe:5vof, PDBj:5vof
PDBsum5vof
PubMed29863725
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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