Structure of PDB 5u6j Chain H

Receptor sequence
>5u6jH (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGT
WYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPF
P
3D structure
PDB5u6j Neutral macrocyclic factor VIIa inhibitors.
ChainH
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 82J H H57 G97 C191 K192 S195 S214 W215 G216 G219 H41 G85 C185 K186 S189 S208 W209 G210 G212 MOAD: Ki=23nM
PDBbind-CN: -logKd/Ki=7.64,Ki=23nM
BindingDB: Ki=610nM
BS02 CA H E70 D72 E75 E80 E58 D60 E63 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5u6j, PDBe:5u6j, PDBj:5u6j
PDBsum5u6j
PubMed28460818
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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