Structure of PDB 5tv3 Chain H

Receptor sequence
>5tv3H (length=225) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKY
AASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNK
TRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVA
LDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRM
KNSPNQRPVQPDYNTVIIKSSAETR
3D structure
PDB5tv3 Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
ChainH
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H63 H88 H90 E94 H107 T169
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN H H110 H112 H129 H88 H90 H107
BS02 7L3 H D107 N108 H110 H112 K133 L190 T191 D85 N86 H88 H90 K111 L168 T169
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5tv3, PDBe:5tv3, PDBj:5tv3
PDBsum5tv3
PubMed28002963
UniProtA0A0M3KL20

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