Structure of PDB 5tqf Chain H

Receptor sequence
>5tqfH (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTW
YLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
3D structure
PDB5tqf Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors.
ChainH
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7KR H L41 C42 H57 K60A D189 S190 K192 S195 S214 W215 G216 Q217 G219 L25 C26 H41 K45 D182 S183 K185 S188 S207 W208 G209 Q210 G211 MOAD: Ki<5nM
PDBbind-CN: -logKd/Ki=8.30,Ki<5nM
BindingDB: Ki=58nM
BS02 CA H E70 D72 E75 E80 E58 D60 E63 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5tqf, PDBe:5tqf, PDBj:5tqf
PDBsum5tqf
PubMed28105277
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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