Structure of PDB 5tci Chain H

Receptor sequence
>5tciH (length=406) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
AIAEPTSHDPDSGGHFGGPSGWGGRYVPEALMAVIEEVTAAYQKERVSQD
FLDDLDRLQANYAGRPSPLYEATRLSQHAGSARIFLKREDLNHTGSHKIN
NVLGQALLARRMGKTRVIAETGAGQHGVATATACALLGLDCVIYMGGIDT
ARQALNVARMRLLGAEVVAVQTGSKTLKDAINEAFRDWVANADNTYYCFG
TAAGPHPFPTMVRDFQRIIGMEARVQIQGQAGRLPDAVVACVGGGSNAIG
IFHAFLDDPGVRLVGFEAAGDGVETGRHAATFTAGSPGAFHGSFSYLLQD
EDGQTIESHSISAGLDYPGVGPEHAWLKEAGRVDYRPITDSEAMDAFGLL
CRMEGIIPAIESAHAVAGALKLGVELGRGAVIVVNLSGRGDKDVETAAKW
FGLLGN
3D structure
PDB5tci A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
ChainH
Resolution2.45 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K101 E123 S390
Catalytic site (residue number reindexed from 1) K98 E120 S387
Enzyme Commision number 4.2.1.20: tryptophan synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 79V H P31 L34 Y200 F202 P208 F211 H294 P28 L31 Y197 F199 P205 F208 H291 MOAD: Kd=132nM
Gene Ontology
Molecular Function
GO:0004834 tryptophan synthase activity
GO:0016829 lyase activity
Biological Process
GO:0000162 tryptophan biosynthetic process
GO:0006568 tryptophan metabolic process
GO:1901605 alpha-amino acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5tci, PDBe:5tci, PDBj:5tci
PDBsum5tci
PubMed28671682
UniProtP9WFX9|TRPB_MYCTU Tryptophan synthase beta chain (Gene Name=trpB)

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