Structure of PDB 5mpc Chain H

Receptor sequence
>5mpcH (length=380) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
AAPYAAKLKQTENDLKDIEARIKEKAGVKESDTGLAPSHLWDIMGDRQRL
GEEHPLQVARCTKIIKKYVINLKQIAKFVVGLGERVSPTDIEEGMRVGVD
RSKYNIELPLPPRIDPSVTMMTVEEKPDVTYSDVGGCKDQIEKLREVVEL
PLLSPERFATLGIDPPKGILLYGPPGTGKTLCARAVANRTDATFIRVIGS
ELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDN
EVQRTMLELITQLDGFDPRGNIKVMFATNRPNTLDPALLRPGRIDRKVEF
SLPDLEGRANIFRIHSKSMSVERGIRWELISRLCPNSTGAELRSVCTEAG
MFAIRARRKVATEKDFLKAVDKVISGYKKF
3D structure
PDB5mpc Structural insights into the functional cycle of the ATPase module of the 26S proteasome.
ChainH
Resolution7.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP H G212 G253 T254 G255 K256 T257 L258 I388 G416 A417 G135 G176 T177 G178 K179 T180 L181 I311 G339 A340
BS02 ATP H D341 R370 D264 R293
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031625 ubiquitin protein ligase binding
GO:0036402 proteasome-activating activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010604 positive regulation of macromolecule metabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5mpc, PDBe:5mpc, PDBj:5mpc
PDBsum5mpc
PubMed28115689
UniProtP33299|PRS7_YEAST 26S proteasome regulatory subunit 7 homolog (Gene Name=RPT1)

[Back to BioLiP]