Structure of PDB 5lpd Chain H

Receptor sequence
>5lpdH (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
3D structure
PDB5lpd Strategies for Late-Stage Optimization: Profiling Thermodynamics by Preorganization and Salt Bridge Shielding.
ChainH
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H L40 L65 R73 T74 R75 Y76 I82 L26 L60 R68 T69 R70 Y71 I78
BS02 71U H H57 Y60A W60D N98 A190 E192 S195 V213 S214 W215 G216 G219 F227 H43 Y47 W50 N95 A194 E196 S199 V219 S220 W221 G222 G224 F233 BindingDB: Ki=0.070000nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5lpd, PDBe:5lpd, PDBj:5lpd
PDBsum5lpd
PubMed31633354
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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