Structure of PDB 5knn Chain H

Receptor sequence
>5knnH (length=446) Species: 9606 (Homo sapiens) [Search protein sequence]
TLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIF
LNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGS
WSFGDYFKELACKMALELLTQEFGIPIERLYVTYFGGDEAAGLEADLECK
QIWQNLGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHL
VNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQN
KMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHAR
TITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVV
VQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDS
KTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQ
3D structure
PDB5knn Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.
ChainH
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.7: alanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A5A H R77 D84 H95 F98 M100 W176 I214 N216 V218 D239 G241 G243 R74 D81 H92 F95 M97 W173 I211 N213 V215 D236 G238 G240
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006419 alanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5knn, PDBe:5knn, PDBj:5knn
PDBsum5knn
PubMed27622773
UniProtP49588|SYAC_HUMAN Alanine--tRNA ligase, cytoplasmic (Gene Name=AARS1)

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