Structure of PDB 5jfd Chain H

Receptor sequence
>5jfdH (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
FG
3D structure
PDB5jfd Strategies for Late-Stage Optimization: Profiling Thermodynamics by Preorganization and Salt Bridge Shielding.
ChainH
Resolution1.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 L40 L65 R73 T74 R75 Y76 K81 I82 F19 L26 L60 R68 T69 R70 Y71 K77 I78
BS02 2TS H H57 Y60A W60D I174 A190 S195 V213 S214 W215 G216 E217 G219 F227 H43 Y47 W50 I173 A194 S199 V219 S220 W221 G222 E223 G224 F233 BindingDB: Ki=0.290000nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5jfd, PDBe:5jfd, PDBj:5jfd
PDBsum5jfd
PubMed31633354
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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