Structure of PDB 5i46 Chain H

Receptor sequence
>5i46H (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB5i46 Atropisomer Control in Macrocyclic Factor VIIa Inhibitors.
ChainH
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 67O H H57 D60 G97 T99 D189 S190 K192 S195 S214 W215 G216 Q217 G219 H41 D44 G85 T87 D186 S187 K189 S192 S211 W212 G213 Q214 G215
BS02 CA H E70 D72 E75 E80 E58 D60 E63 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5i46, PDBe:5i46, PDBj:5i46
PDBsum5i46
PubMed27015008
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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