Structure of PDB 5ebz Chain H

Receptor sequence

>5ebzH (length=655) Species: 9606 (Homo sapiens)

DPEFGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNR
ERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRK
LLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDV
GGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPELFENKPYTATVDYW
SFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFS
SHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMD
HILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELL
SETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSD
CVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSL
LRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSE
KMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGD
LMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRVLKELF
GHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLK
IACTQ

3D structure

• PDB: 5ebz Structural Basis for the Activation of IKK1/ alpha.
• Chain: H
• Resolution: 4.5 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D144 K146 E148 N149 D165 T184
• Catalytic site (residue number reindexed from 1): D139 K141 E143 N144 D160 T179
• Enzyme Commision number: 2.7.11.10: IkappaB kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	5TJ	H	R449 R552	R444 R547
BS02	GLC	H	R563 H592	R558 H587
BS03	PDX	H	H592 Q595	H587 Q590
BS04	5TL	H	L21 T23 V29 M95 E96 Y97 C98 D102 V151 I164 D165	L16 T18 V24 M90 E91 Y92 C93 D97 V146 I159 D160	BindingDB: IC50=1000nM

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5ebz, PDBe:5ebz, PDBj:5ebz
• PDBsum: 5ebz
• PubMed: 27851956
• UniProt: O15111|IKKA_HUMAN Inhibitor of nuclear factor kappa-B kinase subunit alpha (Gene Name=CHUK)