Structure of PDB 5ebu Chain H

Receptor sequence
>5ebuH (length=350) Species: 1377 (Aerococcus viridans) [Search protein sequence]
YNAPSEIKYIDVVNTYDLEEEASKVVPHGGFNYIAGASGDEWTKRANDRA
WKHKLLYPRLAQDVEAPDTSTEILGHKIKAPFIMAPIAAHGLAHATKEAG
TARAVSEFGTIMSISAYSGATFEEISEGLNGGPRWFQIYMAKDDQQNRDI
LDEAKGDGATAIILTADSTVSGNRDRDVKNKFVYPFGMPIVQASKQKISP
RDIEEIAAHSGLPVFVKGIQHPEDADMAIKAGASGIWVSNHGARQLYEAP
GSFDTLPAIAERVNKRVPIVFDSGVRRGEHVAKALASGADVVALGRPVLF
GLALGGWQGAYSVLDYFQKDLTRVMQLTGSQNVEDLKGLDLFDNPYGYEY
3D structure
PDB5ebu Conformational flexibility related to enzyme activity: evidence for a dynamic active-site gatekeeper function of Tyr(215) in Aerococcus viridans lactate oxidase.
ChainH
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S122 Y146 T172 D174 K241 H265
Catalytic site (residue number reindexed from 1) S115 Y139 T165 D167 K217 H241
Enzyme Commision number 1.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN H I41 A92 P93 I94 A95 S122 Q144 Y146 T172 K241 H265 G266 R268 D296 S297 R300 G319 R320 I34 A85 P86 I87 A88 S115 Q137 Y139 T165 K217 H241 G242 R244 D272 S273 R276 G295 R296
BS02 PYR H Y40 Y146 R181 H265 Y33 Y139 R174 H241
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004459 L-lactate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ebu, PDBe:5ebu, PDBj:5ebu
PDBsum5ebu
PubMed27302031
UniProtQ44467|LOX_AERVM L-lactate oxidase

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