Structure of PDB 5do4 Chain H

Receptor sequence
>5do4H (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETANV
GKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACE
GDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQK
VIDQFG
3D structure
PDB5do4 Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
ChainH
Resolution1.859 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna H H87 P88 R89 R98 R123 E169 R170 P171 D183 N184 R245 L246 K248 W249 H87 P88 R89 R98 R123 E167 R168 P169 D181 N182 R243 L244 K246 W247 PDBbind-CN: Kd=1.8pM
BS02 0G6 H H43 Y47 L96 D199 A200 S205 S226 W227 G228 H43 Y47 L96 D197 A198 S203 S224 W225 G226
BS03 CA H R233 K236 R231 K234
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5do4, PDBe:5do4, PDBj:5do4
PDBsum5do4
PubMed27566147
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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