Structure of PDB 4zxx Chain H

Receptor sequence
>4zxxH (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB4zxx Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors.
ChainH
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4T0 H L41 H57 K60A D189 S190 K192 S195 S214 W215 G216 G219 L25 H41 K45 D186 S187 K189 S192 S211 W212 G213 G215 PDBbind-CN: -logKd/Ki=8.10,Ki=8nM
BindingDB: Ki=8.0nM
BS02 CA H E70 D72 E75 H76 E80 E58 D60 E63 H64 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4zxx, PDBe:4zxx, PDBj:4zxx
PDBsum4zxx
PubMed26151189
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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