Structure of PDB 4yhi Chain H

Receptor sequence
>4yhiH (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYYMHWVRQAPGQGLEWMGE
TNPRNGGTTYNEKFKGKATMTRDTSTSTAYMELSSLRSEDTAVYYCTIGT
SGYDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKD
YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTY
ICNVNHKPSNTKVDKKVEPKSC
3D structure
PDB4yhi Structure-guided residence time optimization of a dabigatran reversal agent.
ChainH
Resolution1.9 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4CC H D31 Y33 H35 E50 N52 R54 Y103 D104 Y105 F106 D31 Y33 H35 E50 N52 R54 Y103 D104 Y105 F106 MOAD: ic50=4.6nM
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