Structure of PDB 4ygf Chain H

Receptor sequence
>4ygfH (length=225) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKY
AASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNK
TRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVA
LDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRM
KNSPNQRPVQPDYNTVIIKSSAETR
3D structure
PDB4ygf Structural Basis for the Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase by Sulfonamides.
ChainH
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H63 H88 H90 E94 H107 T169
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN H H110 H112 H129 H88 H90 H107
BS02 AZM H H110 H129 V131 L190 T191 H88 H107 V109 L168 T169 MOAD: Ki=21nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4ygf, PDBe:4ygf, PDBj:4ygf
PDBsum4ygf
PubMed26010545
UniProtA0A0M3KL20

[Back to BioLiP]