Structure of PDB 4x8u Chain H

Receptor sequence
>4x8uH (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGT
WYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPF
P
3D structure
PDB4x8u Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening.
ChainH
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3ZB H D189 S190 K192 V213 W215 G219 G226 V227 Y228 D183 S184 K186 V207 W209 G212 G220 V221 Y222 MOAD: Ki=3.5mM
PDBbind-CN: -logKd/Ki=2.46,Ki=3.5mM
BindingDB: Ki=3500000nM
BS02 CA H E70 D72 E75 E80 E58 D60 E63 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4x8u, PDBe:4x8u, PDBj:4x8u
PDBsum4x8u
PubMed25764119
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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