Structure of PDB 4tuh Chain H

Receptor sequence
>4tuhH (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
GSMSQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRRA
FSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVES
VDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGN
3D structure
PDB4tuh Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL.
ChainH
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 38H H A93 E96 F97 Y101 R102 F105 S106 L108 T109 L130 G138 R139 A142 S145 F146 A149 Y195 A39 E42 F43 Y47 R48 F51 S52 L54 T55 L76 G84 R85 A88 S91 F92 A95 Y141 BindingDB: Ki=0.380000nM,EC50=60nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4tuh, PDBe:4tuh, PDBj:4tuh
PDBsum4tuh
PubMed24944740
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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