Structure of PDB 4ris Chain H

Receptor sequence

>4risH (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]

EVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGI
IYPGDSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARLG
GRYYYDSSGYYYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAA
LGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS
SLGTQTYICNVNHKPSNTKVDKRVEPKS

3D structure

PDB

4ris Structural analysis of the unmutated ancestor of the HIV-1 envelope V2 region antibody CH58 isolated from an RV144 vaccine efficacy trial vaccinee.

Chain

Resolution

2.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	W33 Y52 D54 D56 L95 Y99 Y100 Y100A D100B G100E Y100G	W33 Y52 D55 D57 L99 Y103 Y104 Y105 D106 G109 Y111

External links

PDB	RCSB:4ris, PDBe:4ris, PDBj:4ris
PDBsum	4ris
PubMed	26288844

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