Structure of PDB 4ng9 Chain H

Receptor sequence
>4ng9H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTW
YLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
3D structure
PDB4ng9 Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors.
ChainH
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2KE H H57 D60 G97 T98 T99 D102 D189 S190 K192 S195 S214 W215 G216 G219 H41 D44 G85 T86 T87 D90 D182 S183 K185 S188 S207 W208 G209 G211 PDBbind-CN: -logKd/Ki=7.12,Ki=75nM
BS02 CA H E70 D72 E75 E80 E58 D60 E63 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ng9, PDBe:4ng9, PDBj:4ng9
PDBsum4ng9
PubMed24900796
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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