Structure of PDB 4kuh Chain H

Receptor sequence
>4kuhH (length=280) Species: 632245 (Clostridium butyricum E4 str. BoNT E BL5262) [Search protein sequence]
MKKVFVLGAGTMGAGIVQAFAAKGCEVIVRDIKEEFVDRGIATITKSLSK
LVAKEKITEADKEEILSRISGTTDMKLAADCDLVVEAAIENMKIKKEIFA
ELDGICKPETILASNTSSLSITEVASATKRADKVIGMHFFNPAPVMKLVE
VIRGAATSQETFDAVKEMSESIGKTPVEVAEAPGFVVNRILIPMINEATF
ILQEGVAKEEDIDAAMKLGANHPMGPLALGDLIGLDVCLAIMDVLYNETG
DTKYRASSLLRKYVRAGWLGRKTGKGFYDY
3D structure
PDB4kuh Crystal structure of (S)-3-hydroxybutylryl-CoA dehydrogenase form the n-butanol sysnthesizing bacterium, Clostridium butyricum
ChainH
Resolution2.51 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S117 H138 E150 N188
Catalytic site (residue number reindexed from 1) S117 H138 E150 N188
Enzyme Commision number 1.1.1.157: 3-hydroxybutyryl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CAA H K56 S117 F140 N141 V145 P223 M224 I233 K56 S117 F140 N141 V145 P223 M224 I233
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008691 3-hydroxybutyryl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0070403 NAD+ binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009056 catabolic process
GO:0019605 butyrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4kuh, PDBe:4kuh, PDBj:4kuh
PDBsum4kuh
PubMed
UniProtC4IEM5

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