Structure of PDB 4jzf Chain H

Receptor sequence
>4jzfH (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB4jzf Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.
ChainH
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1NL H Q40 H57 T151 S190 C191 K192 G193 S195 S214 W215 G216 G219 C220 Q24 H41 T141 S187 C188 K189 G190 S192 S211 W212 G213 G215 C216 MOAD: ic50=0.175uM
PDBbind-CN: -logKd/Ki=6.76,IC50=0.175uM
BindingDB: IC50=175nM
BS02 CA H E70 D72 E75 E80 E58 D60 E63 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4jzf, PDBe:4jzf, PDBj:4jzf
PDBsum4jzf
PubMed23927973
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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