Structure of PDB 4ish Chain H

Receptor sequence
>4ishH (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB4ish Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.
ChainH
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1GE H H57 D189 S190 C191 K192 S195 S214 W215 G216 G219 H41 D186 S187 C188 K189 S192 S211 W212 G213 G215 MOAD: Ki=1.9nM
PDBbind-CN: -logKd/Ki=8.72,Ki=1.9nM
BindingDB: Ki=1.9nM
BS02 CA H E70 D72 E75 E80 E58 D60 E63 E68
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ish, PDBe:4ish, PDBj:4ish
PDBsum4ish
PubMed23478148
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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