Structure of PDB 4i9h Chain H

Receptor sequence
>4i9hH (length=329) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]
AALKDQLIHNLLKEEHVPQNKITVVGVGAVGMACAISILMKDLADELALV
DVMEDKLKGEMMDLQHGSLFLRTPKIVSGKDYSVTANSKLVIITAGARQQ
ESRLNLVQRNVNIFKFIIPNVVKYSPHCKLLVVSNPVDILTYVAWKISGF
PKNRVIGSGCNLDSARFRYLMGERLGVHALSCHGWILGEHGDSSVPVWSG
MNVAGVSLKTLHPELGTDADKEQWKQVHKQVVDSAYEVIKLKGYTTWAIG
LSVADLAESIMKNLRRVHPISTMLKGLYGIKEDVFLSVPCVLGQNGISDV
VKVTLTSEEEAHLKKSADTLWGIQKELQF
3D structure
PDB4i9h Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
ChainH
Resolution2.17 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R105 D165 R168 H192
Catalytic site (residue number reindexed from 1) R103 D163 R166 H190
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1E4 H G26 G28 V30 D51 V52 T94 A95 G96 R111 N114 I115 F118 V135 S136 N137 R168 A237 T247 G26 G28 V30 D51 V52 T94 A95 G96 R109 N112 I113 F116 V133 S134 N135 R166 A235 T245 MOAD: Kd=0.068uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4i9h, PDBe:4i9h, PDBj:4i9h
PDBsum4i9h
PubMed23302067
UniProtP13491|LDHA_RABIT L-lactate dehydrogenase A chain (Gene Name=LDHA)

[Back to BioLiP]