Structure of PDB 4hbm Chain H

Receptor sequence
>4hbmH (length=99) Species: 9606 (Homo sapiens) [Search protein sequence]
VPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYL
GQYIMTKRLYHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB4hbm Ordering of the N-terminus of human MDM2 by small molecule inhibitors.
ChainH
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0Y7 H V14 L54 I61 M62 V93 K94 H96 I99 Y100 V7 L47 I54 M55 V81 K82 H84 I87 Y88 MOAD: Kd=12nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4hbm, PDBe:4hbm, PDBj:4hbm
PDBsum4hbm
PubMed22991965
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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