Structure of PDB 4h6d Chain H

Receptor sequence
>4h6dH (length=328) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
DKITFLLNWQPTPYHIPIFLAQTKGYFKEQGLDMAILEPTNPSDVTELIG
SGKVDMGLKAMIHTLAAKARGFPVTSVASLLDEPFTGVLYLKGSGITKSF
QSLKGKKIGYVGEFGKIQIDELTKHYGMKPEDYTAVRCGMNVAKYIIEGK
IDAGIGIECMQQVELEEYLAKQGRPASDAKMLRIDKLCCCFCTVLYICND
EFLKKNPEKVRKFLKAIKKATDYVLADPVKAWKEYIDFKPQLNNDLSYKQ
YQRCYAYFSSSLYNVHRDWKKVTGYGKRLAILPPDYVSNYTNEYLSWPEP
EEVSDPLEATRLMAIHQEKCRQEGTFKR
3D structure
PDB4h6d The Last Piece in the Vitamin B1 Biosynthesis Puzzle: STRUCTURAL AND FUNCTIONAL INSIGHT INTO YEAST 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE (HMP-P) SYNTHASE.
ChainH
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.-.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP H K62 H66 V114 G115 E116 F117 G118 K59 H63 V111 G112 E113 F114 G115
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0106344 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP
Biological Process
GO:0009228 thiamine biosynthetic process
GO:0009229 thiamine diphosphate biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4h6d, PDBe:4h6d, PDBj:4h6d
PDBsum4h6d
PubMed23048037
UniProtP43534|THI5_YEAST 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5 (Gene Name=THI5)

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