Structure of PDB 4gl9 Chain H

Receptor sequence
>4gl9H (length=125) Species: 10090 (Mus musculus) [Search protein sequence]
LKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIR
DSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVL
KLVHHYMGAYYIYKIPLVLSRPLSS
3D structure
PDB4gl9 SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
ChainH
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H G53 R71 S73 S74 T81 N92 R94 L104 Q105 D107 Q112 Y142 Y143 I144 G32 R50 S52 S53 T60 N71 R73 L83 Q84 D86 Q91 Y110 Y111 I112
External links
PDB RCSB:4gl9, PDBe:4gl9, PDBj:4gl9
PDBsum4gl9
PubMed23454976
UniProtO35718|SOCS3_MOUSE Suppressor of cytokine signaling 3 (Gene Name=Socs3)

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