Structure of PDB 4fzb Chain H

Receptor sequence
>4fzbH (length=179) Species: 10506 (Paramecium bursaria Chlorella virus 1) [Search protein sequence]
GSAKLISVTKPVVEGVNTAEELIAYAARVSNTASGLLKYCIRHKHWSIFE
TAFMTLELKTSRGIAAQVLRHRSFHFQEFSQRYASVQTWWATEQEKLYAQ
SMELYNKALEKGIAKECARFILPLSTPTTIYMSGTIRDWIHYIELRTSNG
TQREHIDLANACKEIFIKEFPSIAKALDW
3D structure
PDB4fzb Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.
ChainH
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 FAD H S30 H51 H53 S55 R173 S30 H43 H45 S47 R137
BS02 FAD H Q85 E86 Q77 E78
BS03 0VJ H Q75 R182 G186 Q188 Q67 R146 G150 Q152
BS04 0VJ H F87 S88 Q89 R90 E152 F79 S80 Q81 R82 E116
BS05 FAD H W54 R78 H79 S81 R173 D174 H177 W46 R70 H71 S73 R137 D138 H141
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:4fzb, PDBe:4fzb, PDBj:4fzb
PDBsum4fzb
PubMed23155486
UniProtO41156|THYX_PBCV1 Probable flavin-dependent thymidylate synthase (Gene Name=A674R)

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