Structure of PDB 4e1v Chain H

Receptor sequence

>4e1vH (length=243) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

DVFHLGLTKNDLQGAQLAIVPGDPERVEKIAALMDKPVKLASHREFTSWR
AELDGKAVIVCSTGIGGPSTSIAVEELAQLGIRTFLRIGTTGAIQPHINV
GDVLVTTASVRLDGASLHFAPMEFPAVADFACTTALVEAAKSIGATTHVG
VTASSDTFYPGQERYDTYSGRVVRRFKGSMEEWQAMGVMNYEMESATLLT
MCASQGLRAGMVAGVIVNRTQQEIPNTESHAVKIVVEAARRLL

3D structure

• PDB: 4e1v X-ray structure of Salmonella typhimurium uridine phosphorylase complexed with 5-fluorouracil and molecular modelling of the complex of 5-fluorouracil with uridine phosphorylase from Vibrio cholerae.
• Chain: H
• Resolution: 2.15 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H1008 G1026 R1030 R1048 E1080 R1091 T1094 R1168 I1220 V1221 R1223
• Catalytic site (residue number reindexed from 1): H4 G22 R26 R44 E76 R87 T90 R164 I216 V217 R219
• Enzyme Commision number: 2.4.2.3: uridine phosphorylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	URF	H	T1095 G1096 F1162 Q1166 M1197 I1220	T91 G92 F158 Q162 M193 I216

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004850 uridine phosphorylase activity
• GO:0016757 glycosyltransferase activity
• GO:0016763 pentosyltransferase activity
• GO:0047847 deoxyuridine phosphorylase activity

Biological Process

• GO:0009116 nucleoside metabolic process
• GO:0009164 nucleoside catabolic process
• GO:0009166 nucleotide catabolic process
• GO:0044206 UMP salvage

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4e1v, PDBe:4e1v, PDBj:4e1v
• PDBsum: 4e1v
• PubMed: 22868762
• UniProt: P0A1F6|UDP_SALTY Uridine phosphorylase (Gene Name=udp)