Structure of PDB 4ch8 Chain H

Receptor sequence

>4ch8H (length=259) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE

3D structure

• PDB: 4ch8 Gpibalpha Interacts Exclusively with Exosite II of Thrombin
• Chain: H
• Resolution: 1.75 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H363 D419 E522 G523 D524 S525 G526
• Catalytic site (residue number reindexed from 1): H43 D99 E202 G203 D204 S205 G206
• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E328 G330 M331 P333 W334 D433 H436 P437 C439 Y454 K455 G456 R457 N484 K532 P534 N537 R538 W539	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 G136 R137 N164 K212 P214 N217 R218 W219
BS02	peptide	H	R418 R443 N504 F564 R565 K567 K568	R98 R123 N184 F244 R245 K247 K248
BS03	0G6	H	H363 Y367 L416 D519 A520 G523 S525 W547 G548	H43 Y47 L96 D199 A200 G203 S205 W227 G228

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:4ch8, PDBe:4ch8, PDBj:4ch8
• PDBsum: 4ch8
• PubMed: 24316004
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)