Structure of PDB 4boh Chain H

Receptor sequence
>4bohH (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDAC
EGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ
KVIDQFGE
3D structure
PDB4boh The Tick-Derived Anticoagulant Madanin is Processed by Thrombin and Factor Xa.
ChainH
Resolution2.595 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H H363 Y367 N415 L416 N471 I499 D519 A520 C521 W547 G548 H43 Y47 N95 L96 N151 I178 D198 A199 C200 W226 G227
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4boh, PDBe:4boh, PDBj:4boh
PDBsum4boh
PubMed23951260
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

[Back to BioLiP]