Structure of PDB 3wtw Chain H

Receptor sequence
>3wtwH (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
GPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKP
KMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAM
L
3D structure
PDB3wtw A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
ChainH
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna H Q336 W375 K379 K381 M384 K388 Y396 Q4 W43 K47 K49 M52 K56 Y64
BS02 dna H R391 R394 Y395 Y397 K404 R409 R59 R62 Y63 Y65 K72 R77
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:3wtw, PDBe:3wtw, PDBj:3wtw
PDBsum3wtw
PubMed25083921
UniProtP14921|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)

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