Structure of PDB 3vxf Chain H

Receptor sequence

>3vxfH (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF

3D structure

PDB

3vxf Neutron and X-ray crystallographic analysis of the human alpha-thrombin-bivalirudin complex at pD 5.0: protonation states and hydration structure of the enzyme-product complex

Chain

Resolution

1.602 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	H	I16 E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207	I1 E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N164 M211 K212 N217 R218 W219
BS02	peptide	H	F34 K36 L65 R73 T74 Y76 R77A I82	F19 K21 L60 R68 T69 Y71 R73 I78
BS03	peptide	H	H57 Y60A D189 A190 G193 S195 S214 W215 G216 G219	H43 Y47 D199 A200 G203 S205 S226 W227 G228 G230

External links

PDB	RCSB:3vxf, PDBe:3vxf, PDBj:3vxf
PDBsum	3vxf
PubMed	23712263
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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