Structure of PDB 3vxe Chain H

Receptor sequence

>3vxeH (length=257) Species: 9606 (Homo sapiens)

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQF

3D structure

• PDB: 3vxe Neutron and X-ray crystallographic analysis of the human alpha-thrombin-bivalirudin complex at pD 5.0: protonation states and hydration structure of the enzyme-product complex
• Chain: H
• Resolution: 1.25 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N164 M211 K212 N217 R218 W219
BS02	peptide	H	F34 Q38 L65 R73 T74 R75 Y76 I82	F19 Q24 L60 R68 T69 R70 Y71 I78
BS03	peptide	H	H57 Y60A W60D L99 D189 A190 E192 G193 S195 W215 G216	H43 Y47 W50 L96 D199 A200 E202 G203 S205 W227 G228

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005509 calcium ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0007596 blood coagulation

External links

• PDB: RCSB:3vxe, PDBe:3vxe, PDBj:3vxe
• PDBsum: 3vxe
• PubMed: 23712263
• UniProt: P00734|THRB_HUMAN Prothrombin (Gene Name=F2)