Structure of PDB 3ukh Chain H

Receptor sequence

>3ukhH (length=511) Species: 746128 (Aspergillus fumigatus)

THPDISVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGGLASTDV
TPEGFLYDVGGHVIFSHYKYFDDCLDEALPKEDDWYTHQRISYVRCQGQW
VPYPFQNNISMLPKEEQVKCIDGMIDAALEARVANTKPKTFDEWIVRMMG
TGIADLFMRPYNFKVWAVPTTKMQCAWLGERVAAPNLKAVTTNVILGKTA
GNWGPNATFRFPARGGTGGIWIAVANTLPKEKTRFGEKGKVTKVNANNKT
VTLQDGTTIGYKKLVSTMAVDFLAEAMNDQELVGLTKQLFYSSTHVIGVG
VRGSRPERIGDKCWLYFPEDNCPFYRATIFSNYSPYNQPEASKKLPTMQL
ADGSRPQSTEAKEGPYWSIMLEVSESSMKPVNQETILADCIQGLVNTEML
KPTDEIVSTYHRRFDHGYPTPTLEREGALTQILPKLQDKDIWSRGRFGSW
RYEVGNQDHSFMLGVEAVDNIVNGAVELTLNYPDFVNGRQNTERRLVDGA
QVFAKSKAQLE

3D structure

• PDB: 3ukh Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus.
• Chain: H
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 5.4.99.9: UDP-galactopyranose mutase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FDA	H	G16 P17 T18 D38 S39 G45 L46 G61 G62 H63 V64 V242 M269 R327 E373 Y419 G446 R447 G456 N457 Q458 S461	G15 P16 T17 D37 S38 G44 L45 G60 G61 H62 V63 V241 M268 R326 E372 Y418 G445 R446 G455 N456 Q457 S460
BS02	GDU	H	I65 Y104 F158 M159 Y162 N163 Y317 R327 Y419 Y453 N457	I64 Y103 F157 M158 Y161 N162 Y316 R326 Y418 Y452 N456

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008767 UDP-galactopyranose mutase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0071555 cell wall organization

External links

• PDB: RCSB:3ukh, PDBe:3ukh, PDBj:3ukh
• PDBsum: 3ukh
• PubMed: 22334662
• UniProt: Q4W1X2|GLFA_ASPFM UDP-galactopyranose mutase (Gene Name=glfA)