Structure of PDB 3u98 Chain H

Receptor sequence

>3u98H (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETGQP
SVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGG
PFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
G

3D structure

PDB

3u98 Thrombin Inhibition

Chain

Resolution

1.45 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N157 M204 K205 N210 R211 W212
BS02	peptide	H	F34 L40 L65 R73 T74 R75 Y76 I82	F19 L26 L60 R68 T69 R70 Y71 I78
BS03	BJA	H	H57 Y60A W60D L99 I174 D189 A190 E192 V213 S214 W215 G216 E217 G219 C220	H43 Y47 W50 L96 I172 D192 A193 E195 V218 S219 W220 G221 E222 G223 C224	BindingDB: Ki=1.94nM

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3u98, PDBe:3u98, PDBj:3u98
PDBsum	3u98
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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