Structure of PDB 3qlp Chain H

Receptor sequence
>3qlpH (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
3D structure
PDB3qlp Thrombin-aptamer recognition: a revealed ambiguity.
ChainH
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna H L65 R75 Y76 E77 R77A N78 I79 Y117 L60 R70 Y71 E72 R73 N74 I75 Y114
BS02 0G6 H H57 L99 I174 D189 A190 S195 S214 W215 G216 H43 L96 I179 D199 A200 S205 S226 W227 G228
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3qlp, PDBe:3qlp, PDBj:3qlp
PDBsum3qlp
PubMed21715374
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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