Structure of PDB 3o8o Chain H

Receptor sequence
>3o8oH (length=763) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
PQKAIAVMTSGGDAPGMNSNVRAIVRSAIFKGCRAFVVMEGYEGLVRGGP
EYIKEFHWEDVRGWSAEGGTNIGTARCMEFKKREGRLLGAQHLIEAGVDA
LIVCGGDGSLTGADLFRSEWPSLIEELLKTNRISNEQYERMKHLNICGTV
GSIDNDMSTTDATIGAYSALDRICKAIDYVEATANSHSRAFVVEVMGRNC
GWLALLAGIATSADYIFIPEKPATSSEWQDQMCDIVSKHRSRGKRTTIVV
VAEGAIAADLTPISPSDVHKVLVDRLGLDTRITTLGHVQRGGTAVAYDRI
LATLQGLEAVNAVLESTPDTPSPLIAVNENKIVRKPLMESVKLTKAVAEA
IQAKDFKRAMSLRDTEFIEHLNNFMAINSADHNEPKLPKDKRLKIAIVNV
GAPAGGINSAVYSMATYCMSQGHRPYAIYNGWSGLARHESVRSLNWKDML
GWQSRGGSEIGTNRVTPEEADLGMIAYYFQKYEFDGLIIVGGFEAFESLH
QLERARESYPAFRIPMVLIPATLSNNVPGTEYSLGSDTALNALMEYCDVV
KQSASSTRGRAFVVDCQGGNSGYLATYASLAVGAQVSYVPEEGISLEQLS
EDIEYLAQSFEKAEGRGRFGKLILKSTNASKALSATKLAEVITAEADGRF
DAKPAYPGHVQQGGLPSPIDRTRATRMAIKAVGFIKDNQAAIAEARAAEE
NFNADDKTISDTAAVVGVKGSHVVYNSIRQLYDYETEVSMRMPKVIHWQA
TRLIADHLVGRKR
3D structure
PDB3o8o The Crystal Structures of Eukaryotic Phosphofructokinases from Baker's Yeast and Rabbit Skeletal Muscle.
ChainH
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G206 R270 C271 D301 G345 S346 D348 D350 R392
Catalytic site (residue number reindexed from 1) G12 R76 C77 D107 G151 S152 D154 D156 R198
Enzyme Commision number 2.7.1.11: 6-phosphofructokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6P H R383 R475 R189 R281
BS02 F6P H I347 D348 M390 G391 R392 E447 H481 R484 I153 D154 M196 G197 R198 E253 H287 R290
BS03 FDP H R658 T716 L717 S718 Q761 Q856 R935 R464 T522 L523 S524 Q567 Q662 R741
Gene Ontology
Molecular Function
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3o8o, PDBe:3o8o, PDBj:3o8o
PDBsum3o8o
PubMed21241708
UniProtP16862|PFKA2_YEAST ATP-dependent 6-phosphofructokinase subunit beta (Gene Name=PFK2)

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