Structure of PDB 3iei Chain H

Receptor sequence
>3ieiH (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
GVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKERKAPEINRGYFARV
HGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKDEDLLSSKYFEVDFP
MIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIGADLRD
LSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWAANSFERAM
FINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSNGWE
TASAVDMMELYNRLPRAEVSRIESLEFLDEMELLEQLMRHYCLCWATKGG
NELGLKEITY
3D structure
PDB3iei Structural Insights into Novel Functions of a pro-survival PP2A-specific Methyltransferase
ChainH
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.233: [phosphatase 2A protein]-leucine-carboxy methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH H T29 C30 K37 R73 G98 A99 D122 F123 A170 D171 L172 E198 T5 C6 K13 R49 G74 A75 D98 F99 A146 D147 L148 E174
Gene Ontology
Molecular Function
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006479 protein methylation
GO:0006481 C-terminal protein methylation
GO:0010906 regulation of glucose metabolic process
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032259 methylation
GO:0036211 protein modification process
GO:0042981 regulation of apoptotic process
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3iei, PDBe:3iei, PDBj:3iei
PDBsum3iei
PubMed
UniProtQ9UIC8|LCMT1_HUMAN Leucine carboxyl methyltransferase 1 (Gene Name=LCMT1)

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