Structure of PDB 3hat Chain H

Receptor sequence
>3hatH (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
E
3D structure
PDB3hat Active-site mimetic inhibition of thrombin.
ChainH
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide H F34 L65 R73 T74 R75 Y76 I82 F19 L60 R68 T69 R70 Y71 I78
BS02 peptide H H57 Y60A W60D I174 D189 A190 S195 S214 W215 G216 H43 Y47 W50 I171 D191 A192 S197 S218 W219 G220
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3hat, PDBe:3hat, PDBj:3hat
PDBsum3hat
PubMed15299843
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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