Structure of PDB 3gwc Chain H

Receptor sequence
>3gwcH (length=243) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
ETAPLRVQLIAKTDFLAPPDVPWTTDADGGPALVEFAGRACYQSWSKPNP
KTATNAGYLRHIIDVGHFSVLEHASVSFYITGISRSCTHELIRHRHFSYS
QLSQRYVPEKDSRVVVPPGMEDDADLRHILTEAADAARATYSELLAKLEA
KFADQPNAILRRKQARQAARAVLPNATETRIVVTGNYRAWRHFIAMRASE
HADVEIRRLAIECLRQLAAVAPAVFADFEVTTLADGTEVATSP
3D structure
PDB3gwc Increasing the structural coverage of tuberculosis drug targets.
ChainH
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD H S102 Q103 S100 Q101
BS02 UFP H H91 E92 R95 R199 H89 E90 R93 R197
BS03 FAD H C43 S71 E74 H98 N188 R190 C41 S69 E72 H96 N186 R188
BS04 FAD H R95 H96 R97 H98 H194 R93 H94 R95 H96 H192
BS05 UFP H Q103 S105 Q106 R107 R172 Q101 S103 Q104 R105 R170
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3gwc, PDBe:3gwc, PDBj:3gwc
PDBsum3gwc
PubMed25613812
UniProtP9WG57|THYX_MYCTU Flavin-dependent thymidylate synthase (Gene Name=thyX)

[Back to BioLiP]