Structure of PDB 3gok Chain H

Receptor sequence
>3gokH (length=290) Species: 9606 (Homo sapiens) [Search protein sequence]
FHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML
QDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGE
LFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT
SKRPNAILKLTDFGFAKETTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIL
LCGYPPFYSNISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEP
TQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWE
3D structure
PDB3gok Binding site mapping of protein ligands
ChainH
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207
Catalytic site (residue number reindexed from 1) D141 K143 E145 N146 D162
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4O H L70 V78 A91 K93 L141 D142 L193 D207 L25 V33 A46 K48 L96 D97 L148 D162 BindingDB: IC50=8.5nM,EC50=49nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3gok, PDBe:3gok, PDBj:3gok
PDBsum3gok
PubMed
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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