Structure of PDB 3f6u Chain H

Receptor sequence
>3f6uH (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
LIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKL
LVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATL
SQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLN
FIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFH
GTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRD
3D structure
PDB3f6u Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC).
ChainH
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G193 S195 G196
Catalytic site (residue number reindexed from 1) G189 S191 G192
Enzyme Commision number 3.4.21.69: protein C (activated).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0G6 H H57 T99 N174 D189 A190 S195 S214 W215 G216 H42 T85 N168 D185 A186 S191 S210 W211 G212
BS02 NA H I184A L185 D186A N224 I179 L180 D182 N220
BS03 CA H E70 D72 R75 E80 E56 D58 R61 E66
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3f6u, PDBe:3f6u, PDBj:3f6u
PDBsum3f6u
PubMed12029084
UniProtP04070|PROC_HUMAN Vitamin K-dependent protein C (Gene Name=PROC)

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