Structure of PDB 3eq0 Chain H

Receptor sequence

>3eq0H (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEQPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVID

3D structure

PDB

3eq0 Thrombin Inhibition

Chain

Resolution

1.53 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N155 M202 K203 R209 W210
BS02	peptide	H	F34 L65 R73 T74 R75 Y76 I82	F19 L60 R68 T69 R70 Y71 I78
BS03	2TS	H	H57 Y60A A190 C191 S195 V213 S214 W215 G216 E217 G219 C220 F227	H43 Y47 A191 C192 S196 V216 S217 W218 G219 E220 G221 C222 F230	BindingDB: Ki=0.290000nM

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3eq0, PDBe:3eq0, PDBj:3eq0
PDBsum	3eq0
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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