Structure of PDB 3ecs Chain H

Receptor sequence
>3ecsH (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLT
SAIETLCGVDSSVAVSSGGELFLRFISLSKCKKIMIERGELFLRRISLSR
NKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPD
LSGKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIIN
KIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKEEHPW
VDYTAPSLITLLFTDLGVLTPSAVSDELIKLYLAA
3D structure
PDB3ecs Crystal structure of the alpha subunit of human translation initiation factor 2B
ChainH
Resolution2.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 H S131 R132 V133 K234 S123 R124 V125 K226
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0009408 response to heat
GO:0009749 response to glucose
GO:0014003 oligodendrocyte development
GO:0043434 response to peptide hormone
GO:0044237 cellular metabolic process
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3ecs, PDBe:3ecs, PDBj:3ecs
PDBsum3ecs
PubMed19631657
UniProtQ14232|EI2BA_HUMAN Translation initiation factor eIF2B subunit alpha (Gene Name=EIF2B1)

[Back to BioLiP]