Structure of PDB 3dt0 Chain H

Receptor sequence

>3dt0H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]

IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEGQPS
VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGP
FVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG

3D structure

PDB

3dt0 Understanding Thrombin Inhibition

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.5: thrombin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	H	E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 G136 R137 N159 M201 K202 R206 W207	E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 G136 R137 N156 M203 K204 R210 W211
BS02	peptide	H	F34 Q38 E39 L40 R67 R73 T74 R75 Y76 I82	F19 Q24 E25 L26 R62 R68 T69 R70 Y71 I78
BS03	16U	H	H57 W60D A190 S195 V213 S214 W215 G216 F227	H43 W50 A192 S197 V217 S218 W219 G220 F231

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007596	blood coagulation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3dt0, PDBe:3dt0, PDBj:3dt0
PDBsum	3dt0
PubMed
UniProt	P00734\|THRB_HUMAN Prothrombin (Gene Name=F2)

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