Structure of PDB 2zp0 Chain H

Receptor sequence
>2zp0H (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB2zp0 Peptide Mimetic Factor VIIa Inhibitor: Importance of Hydrophilic Pocket in S2 Site to Improve Selectivity aganist Thrombin
ChainH
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA H E70 D72 E75 E80 E58 D60 E63 E68
BS02 PI0 H H57 D60 G97 T98 P170I D189 S190 C191 K192 S195 V213 S214 W215 G216 G219 H41 D44 G85 T86 P169 D186 S187 C188 K189 S192 V210 S211 W212 G213 G215 PDBbind-CN: -logKd/Ki=7.60,IC50=25nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2zp0, PDBe:2zp0, PDBj:2zp0
PDBsum2zp0
PubMed
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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